Your browser doesn't support javascript.
loading
Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers.
Indian J Exp Biol ; 2014 Jul; 52(7): 720-727
Artículo en Inglés | IMSEAR | ID: sea-153752
ABSTRACT
Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-α), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats. Rutin treatment also improved histo-architecture of ß islets and reversed hypertrophy of hepatocytes. Rutin exhibited significant antidiabetic activity, presumably by inhibiting inflammatory cytokines, improving antioxidant and plasma lipid profiles in High fat diet + streptozotocin induced type 2 diabetic model and may be useful as a diabetic modulator along with standard antidiabetic drugs. However, such effects need to be confirmed on human subjects in clinical condition.
Asunto(s)

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Rutina / Glucemia / Peso Corporal / Femenino / Masculino / Hemoglobina Glucada / Biomarcadores / Interleucina-6 / Factor de Necrosis Tumoral alfa / Ratas Sprague-Dawley Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Indian J Exp Biol Año: 2014 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Rutina / Glucemia / Peso Corporal / Femenino / Masculino / Hemoglobina Glucada / Biomarcadores / Interleucina-6 / Factor de Necrosis Tumoral alfa / Ratas Sprague-Dawley Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Indian J Exp Biol Año: 2014 Tipo del documento: Artículo