Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo.
Indian J Exp Biol
;
2014 Oct; 52(10): 965-971
Artículo
en Inglés
| IMSEAR
| ID: sea-153789
ABSTRACT
In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. α-Amylase inhibitory activities of C. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. Inhibition of α-glucosidase activity by C. asiatica extract, rutin, and acarbose was not different. The in vivo study substantiated the in vitro results. C. asiatica extract (1000 and 2000 mg/4 mL/kg), rutin (1000 mg/4 mL/kg), and orlistat (45 mg/4 mL/kg) significantly decreased plasma glucose, triglyceride and total cholesterol levels in lipid emulsion-induced hyperlipidemic rats at 3 h. However, plasma aspartate aminotransferase and alanine aminotransferase levels did not show significant change. The present work further supports that the C. asiatica extract and its bioactive rutin may help managing hypolipidemic and hypoglycemic effects.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Glucemia
/
Masculino
/
Extractos Vegetales
/
Análisis de Varianza
/
Ratas Wistar
/
Centella
/
Alfa-Glucosidasas
/
Inhibidores de Glicósido Hidrolasas
/
Amilasas
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2014
Tipo del documento:
Artículo
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