Isolation of compound and CNS depressant activities of Mikania scandens Willd with special emphasis to brain biogenic amines in mice.
Indian J Exp Biol
;
2014 Dec; 52(12): 1186-1194
Artículo
en Inglés
| IMSEAR
| ID: sea-153810
ABSTRACT
Mikania scandens, a twining herb that grows as a weed in India and Bangladesh is used as vegetables and is a good source of vitamin A, C, B complex, mikanin, sesquiterpenes, betasitosterin, stigmasterol and friedelin. The present communication reports CNS depressant activities with special emphasis to brain biogenic amines in mice. Ethanol extract of leaves of M. scandens (EEMS) was prepared by Soxhalation and analyzed chemically. EEMS potentiated sleeping time induced by pentobarbitone, diazepam and meprobamate and showed significant reduction in the number of writhes and stretches. EEMS caused significant protection against pentylene tetrazole-induced convulsion and increased catecholamines and brain amino acids level significantly. Results showed that EEMS produced good CNS depressant effects in mice.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Reflejo
/
Convulsiones
/
Tetrazoles
/
Aminas Biogénicas
/
Encéfalo
/
Femenino
/
Masculino
/
Extractos Vegetales
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Depresores del Sistema Nervioso Central
/
Hojas de la Planta
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2014
Tipo del documento:
Artículo
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