New insights in the pathogenesis of type 1 and type 2 lepra reaction.
Indian J Dermatol Venereol Leprol
;
2013 Nov-Dec; 79(6): 739-749
Artículo
en Inglés
| IMSEAR
| ID: sea-154672
ABSTRACT
In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and permanent disabilities. The immunopathogenesis of LR have recently become an important fi eld of research, since it may provide the relevant targets for the early detection and control of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR. Genetic and serum markers in human host may predict susceptibility to reactions as well as progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention of the catastrophic consequences of LR.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Biomarcadores
/
Citocinas
/
Inmunidad Innata
/
Lepra
/
Animales
/
Mycobacterium leprae
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Estudio de tamizaje
Idioma:
Inglés
Revista:
Indian J Dermatol Venereol Leprol
Año:
2013
Tipo del documento:
Artículo
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