Therapeutic efficacy of Nigella sativa Linn. seed extract against CCl4 induced hepatic injury in wistar rats.
Indian J Exp Biol
;
2015 Jan; 53(1): 44-50
Artículo
en Inglés
| IMSEAR
| ID: sea-154993
ABSTRACT
Carbon tetrachloride (CCl4) intake damages liver. We evaluated therapeutic potential of aqueous extract of Nigella sativa seeds against CCl4 induced liver damage in rats. The hepatic damage induced by CCl4 @ 1.5 mL/kg, ip was evidenced by a significant increase in the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, protein and urea lipid peroxidation (LPO) as well as reduction in hepatic antioxidant system e.g. reduced glutathione. Hepatic total protein and glucose-6-phosphatase activity were found decreased. Histological studies substantiated the above biochemical findings. However, after 48 h of administration of aqueous extract of N. sativa seeds (250, 500 and 750 mg/kg, po) it not only detoxified the toxicity but also reversed LPO, GSH, AST, ALT and serum protein changes at all the three doses. Both higher doses of extract were found effective in monitoring urea, albumin, total protein and G-6-Pase activity. However, on the basis of percent protection highest dose i.e., 750 mg/kg proved better. The result suggests that the aqueous extract of N. sativa seeds can be used as a hepatoprotective agent.
Texto completo:
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Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Femenino
/
Tetracloruro de Carbono
/
Extractos Vegetales
/
Nigella sativa
/
Ratas Wistar
/
Relación Dosis-Respuesta a Droga
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2015
Tipo del documento:
Artículo
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