Intravenous methylprednisolone pulse therapy in severe alopecia areata.
Indian J Dermatol Venereol Leprol
;
2015 Jan-Fer ; 81 (1): 95
Artículo
en Inglés
| IMSEAR
| ID: sea-155027
ABSTRACT
Background:
Severe, extensive, therapy resistant alopecia areata represents a clinical challenge. Systemic corticosteroids are a therapeutic tool that still needs to be evaluated.Aim:
The purpose of this study was to assess the efficacy and safety of methylprednisolone pulse therapy in alopecia areata and to find prognostic factors for a favourable outcome.Methods:
A total of 32 patients with severe multifocal alopecia areata (more than 40% scalp hair loss), alopecia totalis, and alopecia universalis were treated with infusions of 500 mg methylprednisolone for 3 days every month for 3 consecutive months. The end point of the study was 12 months.Results:
Of 32 patients, 26 (81.3%) reported a clinical response. Four patients (12.5%) showed complete hair regrowth, 6 patients (18.8%) showed >50% hair regrowth, ten (31.3%) had <50% hair regrowth, 6 (18.75%) were non responders, and another 6 patients (18.8%) had relapse after an initial regrowth. Multivariate analysis revealed that patients reporting at the first episode and those with multifocal disease had the best results.Conclusion:
Methylprednisolone infusions represent a possible therapeutic option for patients with multifocal alopecia areata and those presenting with the first episode of the disease.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Metilprednisolona
/
Niño
/
Adulto
/
Quimioterapia por Pulso
/
Alopecia Areata
/
Adulto Joven
/
Administración Intravenosa
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Dermatol Venereol Leprol
Año:
2015
Tipo del documento:
Artículo
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