Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells.
Indian J Biochem Biophys
;
2014 Dec ; 51(6): 512-519
Artículo
en Inglés
| IMSEAR
| ID: sea-156531
ABSTRACT
Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of colorectal cancers (CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as prostaglandins, thromboxanes and leukotrienes. Over the years, efforts have been made to understand the lipid remodeling pathways and to design anti-cancer drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oxigenasas
/
Fosfolípidos
/
Humanos
/
Transducción de Señal
/
Eicosanoides
/
Regulación Neoplásica de la Expresión Génica
/
Neoplasias del Colon
/
Modelos Inmunológicos
/
Animales
/
Proteínas de Neoplasias
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
2014
Tipo del documento:
Artículo
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