Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!.
Indian J Hum Genet
;
2013 Oct-Dec ;19 (4): 459-464
Artículo
en Inglés
| IMSEAR
| ID: sea-156614
ABSTRACT
INTRODUCTION:
Non‑syndromic tooth agenesis is a congenital anomaly with significant medical, psychological, and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes. AIM OF THE STUDY The aim of this study was to test whether MSX1 671 T > C gene variant was involved in etiology of non‑syndromic tooth agenesis in Raichur patients. MATERIALS ANDMETHODS:
Blood samples were collected with informed consent from 50 subjects having non‑syndromic tooth agenesis and 50 controls. Genomic deoxyribonucleic acid (DNA) was extracted from the blood samples, polymerase chain reaction (PCR) was performed, and restriction fragment length polymorphism (RFLP) was performed for digestion products that were evaluated.RESULTS:
The results showed positive correlation between MSX1671 T > C gene variant and non‑syndromic tooth agenesis in Raichur patients.CONCLUSION:
MSX1 671 T > C gene variant may be a good screening marker for non‑syndromic tooth agenesis in Raichur patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anomalías Dentarias
/
Humanos
/
Distribución de Chi-Cuadrado
/
Factor de Transcripción MSX1
/
India
/
Anodoncia
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Hum Genet
Año:
2013
Tipo del documento:
Artículo
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