Chronic myeloid leukemia in case of Klinefelter syndrome.
Indian J Hum Genet
;
2014 Jan-Mar ;20 (1): 69-71
Artículo
en Inglés
| IMSEAR
| ID: sea-156636
ABSTRACT
Klinefelter syndrome (KS) is a sex chromosome disorder and has been reported to be associated with increased risk for malignancies. We report a 22‑year‑old male patient who was diagnosed to have chronic myeloid leukemia in chronic phase. Bone marrow cytogenetic examination revealed karyotype 47, XXY, t (9; 22)(q34, q11) suggestive of KS with presence of Philadelphia chromosome. The patient was treated with oral imatinib mesylate (400 mg/day). Complete hematological response was achieved after 2 months of therapy. The bcr‑abl/abl transcript percentage measured from peripheral blood at baseline, 1 and 2 years after imatinib were 97%, 1.99%, 0.007%, respectively. He remains in complete hematological and major molecular remission after 2 years of continued imatinib therapy.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Piperazinas
/
Pirimidinas
/
Humanos
/
Masculino
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Adulto Joven
/
Síndrome de Klinefelter
Idioma:
Inglés
Revista:
Indian J Hum Genet
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS