Weak D antigen - Revisited.
Artículo
en Inglés
| IMSEAR
| ID: sea-157332
ABSTRACT
D antigen is the most immunogenic antigen in the complex Rh blood group system discovered in the year 1939. There is a lot of polymorphism in its phenotype due to genetic heterogeneity. Certain mutations and /or deletions lead to a weak phenotype defined by decreased density of antigen sites which require the use of anti human globulin for detection. The need for detection of the weak D antigen was to prevent alloimmunization by this blood if transfused to a D negative patient especially to women in child bearing age group. This contention is however, controversial and not proven beyond doubt. Moreover, the use of potent monoclonal D typing antisera detects low density of weak D antigens thus obviating the use of anti human globulin. We have assessed the incidence of Rh negative and weak D blood groups in the Garhwal region of Uttarakhand and reviewed the literature regarding the controversies in the clinical significance of weak D antigen.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Sistema del Grupo Sanguíneo Rh-Hr
/
Isoinmunización Rh
/
Femenino
/
Humanos
/
Inmunoglobulinas
/
Tipificación y Pruebas Cruzadas Sanguíneas
/
Incidencia
/
Inmunización
/
Globulinas
/
India
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2011
Tipo del documento:
Artículo
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