Significance of gammaglutamyl transferase estimation in hepatobiliary diseases.

ABSTRACT

The present study was conducted to evaluate the significance of gamma glutamyl transferase (GGT) in hepatobiliary diseases and made to prove the GGT as a significant differential factor in diagnosis of high serum alkaline phosphatase conditions. In 166 patients of hepatobiliary diseases.The results were compared with 32 healthy age matched volunteers, patients were subjcted to detailed clinical examination and laboratory investigations. Blood samples were collected for estmation of serum Bilirubin, AST, ALT, ALP and GGT. Ratio of serum AST/ALT and serum ALP levels were significantly (P<0.001) increased in alcoholic liver disease and hepatic carcinoma. The results give enough evidence of increased GGT in microsomal induction by alcohol and other factors.