Cord Serum Screening Test and the Newborns Allergic Status.
Indian Pediatr
;
2009 Apr; 46(4): 295-299
Artículo
en Inglés
| IMSEAR
| ID: sea-15794
ABSTRACT
OBJECTIVE:
To evaluate the predictive value of a cord serum screen test and possible subsequent development of allergic disease in infants.DESIGN:
Cohort study.SETTING:
100 pregnant women were randomly recruited for the study.METHODS:
The maternal serum and the cord serum of their matched newborn were analyzed for total serum immunoglobulin E (IgE), gamma interferon (g IFN), house dust mite- Dermatophagoides pteronyssinus allergen (Der p1) and Blomia tropicalis allergen (Blo t5) using immunoassay methods. All infants were followed up for one year.RESULTS:
Infants who had allergic diseases in the one year follow-up (n=45) had significantly (P < 0.001) elevated IgE, Der p1, Blo t5, and significantly low g IFN levels in cord serum as compared to the same parameters of infants who did not develop allergic disease in the one year follow-up (n=43).CONCLUSION:
In utero exposure to HDM allergens Der p1 and Blot5 is prevalent. We have successfully established a cord serum screening test for predicting allergic diseases in infancy with 93% specificity and sensitivity.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Inmunoglobulina E
/
Recién Nacido
/
Embarazo
/
Cisteína Endopeptidasas
/
Alérgenos
/
Valor Predictivo de las Pruebas
/
Estudios de Seguimiento
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
2009
Tipo del documento:
Artículo
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