Spectrophotometric determination of fluvoxamine as maleate by selective methods.

ABSTRACT

Simple, accurate and reproducible visible spectrophotometric methods for the assay of drug fluvoxamine as maleate were established based on the formation of oxidative coupling reaction between the corresponding drug, Brucine-NaIO4 and DCQC. The procedures described were applied successfully to the determination of the compound in their dosage forms. The results showed that the proposed procedures compared favorably with the reference methods and satisfactory sensitivity, accuracy and precision. The optical characteristics such as Beer’s law limits, molar absorptivity and sandell’s sensitivity are reported. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for the drug.