Hematological profile of sickle cell disease: A hospital based study at CIMS, Bilaspur, Chhattisgarh.

Hematological profile of total 1260 individuals were tested for Sickle Cell Disease who attended CIMS OPD, Bilaspur during a period of May 2008 to October 2009 is presented here. At least 4.44% of the total subjects tested were identified as homozygous for sickle cell gene (SS) and 35% were with sickle cell trait (AS). The patients were confirmed by examining the blood samples for solubility test and hemoglobin electrophoresis using cellulose acetate membrane. Among the SS patients about 58% were males and 42% were females and their ages vary from 7 months to 65 years. The SS patients showed comparatively low level of hemoglobin as well as the RBC count in both the sexes than the AS or normal subjects (AA). PCV was higher in males (31.44±3.1%) than in females (28.62±3.6%). Average MCH and MCHC did not show any significant difference between the sexes. MCV and MCHC were found to be quite higher in SS subjects than AS or AA. Thus in absence of any definite data this investigation may put some insight on the incidence of sickle cell disease in Chhattisgarh.