The comparisons of the efficacy and toxicity between gefitinib and docetaxel for patients with advanced nonsmall-cell lung cancer: A meta-analysis from randomized controlled clinical trials.
Indian J Cancer
;
2014 Mar; 51(7_Suppl): s86-s91
Artículo
en Inglés
| IMSEAR
| ID: sea-158223
ABSTRACT
BACKGROUND:
The extent of the benefit of gefitinib in the treatment of advanced nonsmall‑cell lung cancer (NSCLC) is till controversial, when compared with docetaxel. We performed this meta‑analysis to compare the efficacy and toxicity of gefitinib with docetaxel for different patients with advanced NSCLC. MATERIALS ANDMETHODS:
We searched PubMed, Cochrane Library, and identified 5 randomized controlled clinical trials published within 2000–2013. After further full‑text screening, 4 clinical trials were included in the final meta‑analysis.RESULTS:
The outcomes of treatment efficacy included progression‑free survival (PFS), overall survival (OS) and objective response rate (ORR). Comparing gefitinib to docetaxel for advanced NSCLC patients, the pooled hazard ratio (HR) of PFS was 0.91, (95% confidential index [CI] = 0.83–0.99), the pooled HR of OS was 1.02, (95% CI = 0.93–1.13), the pooled risk ratio of ORR was 1.57, (95% CI = 1.01–2.47).CONCLUSIONS:
Gefitinib was found to significantly improve patients’ PFS and response rate compared with docetaxel. There is no difference of OS between gefitinib and docetaxel.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Tipo de estudio:
Ensayo Clínico Controlado
/
Revisiones Sistemáticas Evaluadas
Idioma:
Inglés
Revista:
Indian J Cancer
Año:
2014
Tipo del documento:
Artículo
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