Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy.
Indian J Ophthalmol
;
2015 Apr; 63(4): 318-322
Artículo
en Inglés
| IMSEAR
| ID: sea-158621
ABSTRACT
Purpose:
To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC).Methods:
Patients with acute macular SC with lesions threatening and/ or involving fovea were enrolled. All patients received CyP (1 g/m2) for 3 days followed by high‑dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects.Results:
Eight patients (seven unilateral and one bilateral) with median age of 27 years (range 13-40 years) were recruited. Mean visual acuity at presentation was 0.71 ± 0.35 logarithm of the minimum angle of resolution while postpulse visual acuity was 0.40 ± 0.32. Final mean visual acuity at 1‑year was 0.31 ± 0.23 (P ≤ 0.05). Three eyes had recurrence and 3 patients developed transient hair loss with no other adverse effect.Conclusion:
Intravenous CyP provides rapid resolution of lesion activity and thereby helps in maintaining good functional acuity.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Idioma:
Inglés
Revista:
Indian J Ophthalmol
Año:
2015
Tipo del documento:
Artículo
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