Multiple Regression Analysis Of Biochemical And Immunological Parameters In Essential Hypertension.

ABSTRACT

Data on 134 cases diagnosed for essential-hypertension (EHT) and studied for eight biochemical and five immunological parameters (blood sugar, blood urea, serum creatinine, serum cholesterol, serum protein, haptoglobin, Lactate dehydrogenase (LDH), ceruloplasmin, Ig-G, Ig-A, antinuclear antibody (ANA) T and B cell populations) along with 180 normotensive controls were computerised for their contributions by using the forward selection procedures of selecting the best regression equation (Draper and Smith, 1981). When biochemical parameters alone were considered, they contributed 10.0 per cent to the variation in diastolic blood pressure of which the contribution due to haptoglobin was 6.59 per cent and serum creatinine 3.41 per cent. When biochemical and immunological parameters were considered, only LDH contributed 15.30 per cent to the variation in diastolic blood pressure. When the data was grouped based on the expected diastolic pressure (mm/Hg;) into low risk (80-100) medium risk (101-110) and high risk (111-120) groups, males were found to be more prone in general. In the medium risk group 30.98per cent and high risk group 27.78per cent of the cases showed Positive family history while all the cases with low risk were non-familial. Among the familial cases compared to males, females were found to be 2.67 times higher in medium and 1.5 times higher in high risk groups suggesting greater involvement of genetic component in females and non-genetic and / or physiological factors in males.