Study Of Malformations And Down Syndrome In India (SOMDI) : Bombay Region.

ABSTRACT

As a part of the multicentric BRNS project on the incidence of congenital malformations and Down syndrome, Mumbai centre examined a total of 42,304 babies delievered at K.E.M. Hospital and Nowrosjee Wadia Maternity Hospital (NWMH). Among the major malformations recorded 5.58 were of musculoskeletal system 5.22 of gastrointestinal system, 4.89 of gastrointestinal system, 2.88 of urinogenital system, 1.82 cardiovascular system and other less than 1 per 1000 birth. Among the minor varieties of dismorphism hand and feet showed maximum frequency followed by ears and eyes. Details of these malformations with reference to clinical features; chromosmal analysis and demographic data are discussed.