Effect of diabetes mellitus on the pharmacokinetic behavior of gatifloxacin in sprague-dawley rats.

ABSTRACT

Effects of diabetes mellitus induced by streptozotocin (DMIS) on the pharmacokinetics of Gatifloxacin were investigated after i.v and oral administration (50mg/mg) to control Sprague-Dawley rats and DMIS rats (at 7th and 29th days after administration of streptozotocin (55mg/kg). After i.v administration to DMIS rats, there was no significant difference in clearance, t1/2, Vd and MRT last. But after oral administration of gatifloxacin to DMIS rats Cmax was significantly increased. This could be supported with the marginal increase in AUC and an increase in bioavailability of drug in chronic (78.7% increase) as well as acute conditions (75.3% increases). Streptozotocin induced toxicity did not influence considerably on the pharmacokinetics of gatifloxacin.