Retinoic acid and mammalian craniofacial morphogenesis.

ABSTRACT

Retinoic acid is a morphogenetic signalling molecule in vertebrate embryos, one being known to perform a specific function in organizing the body pattern along the anteroposterior axis. This molecule has especially attracted research attention because retinoic acid treatment will also induce abnormal morphogenesis, particularly in the craniofacial structures. The present review discusses recent molecular insights revealing how the retinoic acid signal is transduced within a cell, specifically focusing on the involvement of cranial neural crest cells in retinoic acid-induced abnormal morphogenesis in the mammalian head.