Innovations in tablet coating technology: A review.

ABSTRACT

Solid dosage forms are coated for a number of reasons, the most important of which is controlling the release profiles and bioavailability of the active ingredient. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Tablets are usually coated in horizontal rotating pans with the coating sprayed onto the free surface of the tablet bed. Tablets must have a coating mass that lies within a prescribed range with very little inter- and intra-tablet coating variability. Using the Discrete Element Method (DEM), tablet coating can be simulated on the computer. Simulation data provide the position, velocity, and orientation of each tablet within the coater, allowing accurate measurements of the time and orientation that each tablet spends exposed to the coating spray.