Comparative effect of calcium mupirocin and fluticasone on experimentally induced burn wound healing in rats.

ABSTRACT

Topical antibiotic like Calcium mupirocin and its combination with steroid Fluticasone are commonly used to treat burn wounds. But whether they influence healing of wounds is not known. Aim: To compare the effect of Calcium mupirocin and Fluticasone of Apex Laboratories Chennai, on experimentally induced burn wound healing in Wistar rats and compare with available market preparation Mupirocin and Fluticasone -mupirocin combination. Method: Partial thickness burn wound was inflicted, on Wistar rats under ketamine (50mg/kg/i.p) by pouring hot molten wax at 80◦ C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group I did not receive any drug and served as control group. Group II, III, IV, V, VI, and VII received Calcium mupirocin A, Calcium mupirocin B, Mupirocin, Fluticasone+Calcium mupirocin A combination. Fluticasone +Calcium mupirocin B combination and Fluticasone -mupirocin combination creams respectively, twice a day for 21 days or till complete healing whichever was earlier. Results: Calcium mupirocin significantly decreased the duration of epithelialization and increased % of wound contraction in comparison to the control group. This was confirmed by Histopathology studies. Conclusion: Calcium mupirocin of apex possess significant wound healing properties.