In vitro Antioxidant, Cytotoxic and Antibacterial Screening of the leaves of Acridocarpous orientalis, Native to Sultanate of Oman.
Artículo
en Inglés
| IMSEAR
| ID: sea-163309
ABSTRACT
Aims:
To determine antioxidant, cytotoxic and antimicrobial activities of organic extracts from leaves of Acridocarpous orientalis (qafas) from Sultanate of Oman. StudyDesign:
Brine shrimp test, DPPH assay and Disc diffusion method. Place and Duration of Study School of Pharmacy, University of Nizwa, Oman, December 2012.Methodology:
Hexane, chloroform, ethylacetate and hydroalcoholic extract were obtained by Kupchan’s partitioning of ethanol extract isolated from leaves of A. orientalis by maceration. Antioxidant activity was determined by free radical scavenging of (2,2- diphenyl-1-picrylhydrazyl, DPPH). The antimicrobial activity was checked using agar disc diffusion method against Gram-positive bacteria (Staphylococcus aureus) and two Gramnegative bacteria (Escherichia coli and Pseudomonus aeruginosa). Brine shrimp test was used to measure cytotoxic activity.Results:
All extracts demonstrated potential antioxidant activities, hydroalcoholic extract showed the strongest activity (RC50 = 6.11 g/ml). The order of antioxidant activity was hydro alcohol > ethyl acetate > chloroform > hexane extract. Ethylacetate extract showed low activity against Pseudomonus aeruginosa. None of the extracts was found to be active against brine shrimp larvae.Conclusion:
A. orientalis could be considered as a good source of antioxidant compounds.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Omán
/
Técnicas In Vitro
/
Hojas de la Planta
/
Malpighiaceae
/
Antiinfecciosos
/
Antibacterianos
/
Antineoplásicos
/
Antioxidantes
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS