Electrophysiological changes in acute guillain-barre syndrome.

ABSTRACT

Aim: To study the various electrophysiological changes in the motor conduction, sensory conduction and F wave latencies of acute Guillain-Barre Syndrome patients. Methods: Sixteen patients with acute GBS were included in this study. They were subjected to various nerve conduction studies (NCS) following standardized procedures. The mean values obtained for the various nerve conduction parameters were compared against the corresponding standardized values using Student’s t-test. P value less that 0.05 was considered significant. Results: The results of NCS in GBS patients were as follows 1.The motor nerve conduction velocity was significantly lower and the motor nerve conduction latency was significantly prolonged. 2. The sensory nerve action potential conduction velocity and amplitude remained normal in most of these individuals. 3. F wave latency was significantly prolonged. Conclusion: Acute Guillain-Barre Syndrome patients manifest with abnormal motor nerve conduction parameters and F wave latency. Electrophysiological studies would help the researchers to diagnose the disease at an early stage.