Superoxide anions mediate proliferative response in cardiac fibroblasts.
Artículo
en Inglés
| IMSEAR
| ID: sea-16443
ABSTRACT
The study was undertaken to examine whether superoxide anions mediate a proliferative response in cardiac fibroblasts. Cardiac fibroblasts isolated from newborn Wistar rats were exposed to superoxide anion generating system (hypoxanthine + xanthine oxidase) and its effect on cell growth was assessed. A stimulatory response on fibroblast proliferation was observed. The proportion of proliferating cells increased within 3 h of treatment compared to the control and the cell density after 96 h of exposure remained significantly high (P < 0.0005). Inclusion of antioxidants neutralised the stimulatory response, fortifying the role of superoxide anions in cell proliferation. This observation indicates that superoxide anions can mediate a fibrotic reaction in the cardiac tissue.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
División Celular
/
Células Cultivadas
/
Ratas Wistar
/
Superóxidos
/
Antígeno Nuclear de Célula en Proliferación
/
Fibroblastos
/
Animales
/
Miocardio
Idioma:
Inglés
Año:
2000
Tipo del documento:
Artículo
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