Pre-Clinical Screening of Indigenous Medicinal Plant Phyllanthus Amarus for its Analgesic Activity.

ABSTRACT

Background: Phyllanthus amarus aqueous extract was investigated for its central and peripheral analgesic activities. Objectives: To evaluate the central and peripheral analgesic activities of aqueous extract of Phyllanthus amarus. Materials and Methods: The aqueous extract of Phyllanthus amarus was prepared using soxhlet apparatus. An in vivo study using Swiss albino mice was done to screen the central and peripheral analgesic activity of P.amarus extract. The extract was administered at a dose of 100 mg/kg body weight I.P. The peripheral analgesic activity was assessed using acetic acid induced writhing test.The central analgesic activity was assessed using Eddy’s hot plate apparatus. Results: The aqueous extract of P.amarus showed significant (p<0.05) peripheral and central analgesic activity.Conclusion: This study demonstrated that P.amarus aqueous extract exhibited significant analgesic activities.