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Glycobiology of Leishmania donovani.
Artículo en Inglés | IMSEAR | ID: sea-17016
ABSTRACT
Leishmania donovani, the causative organism of visceral leishmaniasis (VL) is one of the deadliest of the entire known Leishmania species. This protozoan parasite displays immense adaptability to survive under extremely harsh conditions. Cell surface glycoconjugates play a pivotal role in parasite virulence and infectivity. This review mainly highlights on the importance of these molecules and their reported roles with special emphasis on L. donovani sialobiology. The recently evolved information reported by our group regarding the identification and characterization of sialoglycans and their possible mode(s) of acquisition as also the detailed identification, characterization of anti-O-acetylated sialic acid (anti-OAcSA) antibodies and their emerging biological roles, notably as molecules that may aid in host defense against the pathogen has been vividly discussed in this review.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Polisacáridos / Leishmania donovani / Glicoconjugados / Glicoproteínas / Membrana Celular / Cromatografía Líquida de Alta Presión / Ácido N-Acetilneuramínico / Animales / Microscopía Fluorescente Idioma: Inglés Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Polisacáridos / Leishmania donovani / Glicoconjugados / Glicoproteínas / Membrana Celular / Cromatografía Líquida de Alta Presión / Ácido N-Acetilneuramínico / Animales / Microscopía Fluorescente Idioma: Inglés Año: 2006 Tipo del documento: Artículo