Uterine Volume and Blood Flow Changes in the Uterus Induced by GnRH Analogues in Cases of Fibroids

ABSTRACT

This prospective study was conducted to study the effect of gonadotropin releasing hormone ( GnRH) agonist on uterine and fibriod volume and the changes in blood flow in the uterine vessels. Nine patients with symptomatic fibriods, not willing for surgery, were enrolled. All patients recieved minimum 3 injections of GnRH agonist at 4 weeks interval. Uterine and fibroid volume and blood flow in the utrine vessels was measured before and three months after treatment. There was decrease in the fibriod volume and increase in resistance index in uterine arteries. There was no significant decrease in uterine volume. Out of four perimenopausal women two achieved menopause. GnRH agonist may have a role in perimenopausal women with symptomatic fibroid.