Luteal Phase Estradiol & Progesterone Levels in Relation to Symptom Severity in Patients with Premenstrual Syndrome.

ABSTRACT

Premenstrual syndrome is characterized by disturbing somatic and behavioural symptoms that develop after ovulation, reach a maximum during premenstrual days and disappear four days after the onset of menstruation. The aim of present study is to investigate the relationship between serum levels of estradiol and progesterone in luteal phase and PMS symptom severity in patients with PMS. We selected sixty young healthy adult females in the age group 15 and 30 and rated them for PMS symptoms. Daily blood samples were taken in follicular phase (5-8 days) and luteal phase(22-26 days). Serum estradiol and progesterone were analyzed using commercial RIA kit. Based on premenstrual hormone concentrations patients were divided into groups with high, normal and low hormonal levels. It was found that in females with a premenstrual increase in serum estradiol and decrease in serum progesterone levels , symptoms were 70 % and 70.6 % respectively, (p<0.01for both) which is statistically significant .