Bacterial Isolates and their Antibiotic Sensitivity Pattern in Clinically Suspected Cases of Fever of Unknown Origin.

ABSTRACT

The present study was conducted on 100 suspected cases of fever of unknown origin to identify the prevalence of predominant bacterial microorganisms and their drug sensitivity pattern. The blood samples were subjected to conventional blood culture and BACTEC 9050 culture system. Out of 100 suspected cases, culture positivity was seen in 46% cases with 80.43% pathogenic bacterial isolates comprising of 54.05% gram positive and 45.94% gram negative isolates. Predominant gram positive isolates were coagulase negative Staphylococcus 35% followed by 30% Staphylococcus aureus with sensitivity to vancomycin (100%) and resistance to ampicillin, cloxacillin & cefalexin. Gram negative isolates were Salmonella typhi (29.41%) followed by E coli (17.64%) showing sensitivity to piperacillin/tazobactum and cefoperazone/sulbactum (90%) each and resistance to amoxicillin. BACTEC 9050 was observed to be sensitive(100%) as compared to conventional blood culture(67.56%) for cultural isolation of pathogenic organisms in clinical specimens.