Anti-granuloma activity of Coriandrum sativum in experimental models.

ABSTRACT

Background: Coriandrum sativum has been used in the traditional systems of medicine for management of arthritis and other infl ammatory disorders. Objectives: In this study, we have evaluated the anti-infl ammatory and anti-granuloma activities of Coriandrum sativum hydroalcoholic extract (CSHE) in experimental models. Materials and Methods: The anti-infl ammatory activity of CSHE was evaluated using carrageenan-induced paw edema model and the anti-granuloma activity of CSHE was evaluated using the subcutaneous cotton pellet implantation-induced granuloma formation and stimulation of peritoneal macrophages with complete Freund’s adjuvant. Serum tumor necrosis factor- (TNF-), IL-6, IL-1  levels, and peritoneal macrophage expression of TNF-R1 were evaluated as markers of global infl ammation. Results: CSHE at the highest dose tested (32 mg/kg) produced a signifi cant reduction (P0.05) in paw edema after carrageenan administration. CSHE treatment also reduced dry granuloma weight in all treated animals. Serum IL-6 and IL-1  levels were signifi cantly (P0.05) lower in the CSHE (32 mg/kg)-treated group as compared to control. Although there was an increase in serum TNF- level in the CSHE-treated group as compared to control, TNF-R1 expression on peritoneal macrophages was found to be reduced. Conclusion: Thus, the result of this study demonstrates the anti-infl ammatory and anti-granuloma activities of CSHE in experimental models, and validates its traditional use for the management of arthritis and other infl ammatory disorders.