Hematologic, liver enzymes and electrolytes changes in chronic myeloid leukemia after Imatinib medication.

BACKGROUND: Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15‑20% of all adulthood leukemia. AIMS: This study aimed to compare the hematologic, breakpoint cluster region‑abelson (BCR‑ABL) and liver function enzymes changes during treatment period of Imatinib. SETTINGS AND DESIGN: A noncurrent clinical trial study. MATERIALS AND METHODS: New incident CML patients received Iranian made or Indian‑made Imatinib after baseline measurement. Hematologic, BCR‑ABL, electrolytes and liver function enzymes measured again after 24 weeks. STATISTICAL ANALYSIS USED: Paired t‑test and independent t‑test was used to assess the effect of treatment in within and between groups, respectively. RESULTS: Imatinib has a decreasing impact on white blood cells and placates. While an increasing effect on hemoglobin concentration. Iranian made and Indian‑made Imatinib has a same effect on improvement of hematologic, BCR‑ABL, electrolytes in CML patients. However, the liver changes of Imatinib were not clinically significant. CONCLUSION: The Iranian‑made Imatinib can be used as a replacement for Indian made ones without any statistical and clinical significant difference on Improvement of CML patients.