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Pharmacologic characterization of muscarine receptor subtypes in rat gastric fundus mediating contractile responses.
Artículo en Inglés | IMSEAR | ID: sea-17407
ABSTRACT
The role of four muscarinic receptor subtypes M1, M2, M3 and M4 which have been characterized pharmacologically was examined in motility control of isolated rat gastric fundus. Acetylcholine produced concentration-dependent tonic contraction of isolated rat fundus (EC50 = 9.64 +/- 0.14 x 10(-8)M). These contractions were concentration-dependently antagonized by atropine (KB = 2.45 x 10(-11)M), M1 selective blockers telenzepine (KB = 6.64 x 10(-11)M) and pirenzepine (KB = 2.3 x 10(-8)M), and hexocyclium (KB = 2.82 x 10(-10)M). M3-selective blocker p-fluoro-hexahydro-sila-difenidol (pFHHSiD) was a less potent antagonist (KB = 2.3 x 10(-8)M), while M2 and M4-selective methoctramine produced only weak blockade of tonic contractions caused by acetylcholine (KB = 4.68 x 10(-6)M). These results suggest that only M1 and M3 muscarinic receptors have functional roles in motility control of rat gastric fundus, M1 receptors being more important.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Piperazinas / Piperidinas / Ratas / Atropina / Pirenzepina / Femenino / Masculino / Acetilcolina / Receptores Muscarínicos / Ratas Wistar Idioma: Inglés Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Piperazinas / Piperidinas / Ratas / Atropina / Pirenzepina / Femenino / Masculino / Acetilcolina / Receptores Muscarínicos / Ratas Wistar Idioma: Inglés Año: 1997 Tipo del documento: Artículo