Prevalence of VKORC1 Polymorphism in Population of Hyderabad India.
Artículo
en Inglés
| IMSEAR
| ID: sea-177542
ABSTRACT
Introduction:
Warfarin/Acitrom administration dosage varies based on patient genotype with respect to the gene Vitamin K epoxide reductase complex 1 (VKORC1). Ethnic diversity contributes to genotype variation. The frequency of polymorphism at VKORC1 in population of Hyderabad has not been reported in literature; hence the present study was conducted. Material &Methods:
Genomic DNA from peripheral blood leukocytes of patients on warfarin/acitrom as well as normal control population without any thrombotic disease was extracted and Restriction Fragment Length Polymorphism (RFLP) pattern was established for 1173C>T transition by standard protocols.Result:
The incidence of homozygote dominants (CC) genotypes were 74.63% and that of heterozygotes (CT) were 25.37 %. No recessives were found in the study group.Conclusion:
Presently genotype based dosage is not implemented. This study through its collaboration with practising cardiologist while establishing the test at our diagnostic centre has also enabled awareness and consequently if followed will improve patient safety.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio de prevalencia
Idioma:
Inglés
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS