Maternal Risk Factor for Seizures in Term Neonate: A Hospital –Based Case Control Study.

ABSTRACT

Background: Assessing the maternal risk factors for seizure in first 72 hours of life in term neonate. Design: Case control study. Setting: Department of Paediatrics, Neonatology unit and Maternity ward tertiary care centre Govt. Medical College, Nagpur. Methods: A 210 cases [Term neonate with seizure within first 72 hours of life] and 210 controls [Term neonate without seizure in first 72 hours of life] were randomly selected as study subject over a period of two year. Primary exposure variables in mothers including age, parity, diabetes mellitus, hypertension, anemia, intrapartum fever, mode of delivery and prolonged second stage of labor were considered in study population. Neonates were carefully examined and observed for seizures and manage accordingly. Results: Maternal diabetes mellitus and anemia were potentially significant in their association with term neonatal seizure while maternal hypertension, intrapartum fever and prolonged second stage of labor were not significantly associated with seizure. Neonates born to diabetic mother, young maternal age, anemic mother and cesarean delivered neonate had 1.97, 0.95, 1.83 and 2.18 time more risk to developed seizure respectively. Conclusion: Early identification and timely intervention of maternal risk factor may reduces the seizure in term neonate.