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Genetic perspective of retinoblastoma: From present to future.
Indian J Ophthalmol ; 2016 May; 64(5): 332-336
Artículo en Inglés | IMSEAR | ID: sea-179260
ABSTRACT
Retinoblastoma (RB) is the most common malignant intraocular tumor in children. In the last decade, basic research has led to a better understanding of events after two hits in RB susceptibility gene (RB1), molecular mechanism of tumor growth, the cell of origin of RB, etc. This would pave way to identify biomarkers and molecular targeted therapy for better treatment option in the future. Furthermore, improvement in molecular techniques has led to enhanced diagnostic methods for early diagnosis, genetic counseling, and prevention of the disease. This review will help to understand the essence of basic research work conducted in recent times and its implication in the management of RB in the future.

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Tipo de estudio: Estudio de tamizaje Idioma: Inglés Revista: Indian J Ophthalmol Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Tipo de estudio: Estudio de tamizaje Idioma: Inglés Revista: Indian J Ophthalmol Año: 2016 Tipo del documento: Artículo