Relation of cerebrospinal fluid/plasma HIV-RNA discordance with neurocognitive impairment.
Artículo
en Inglés
| IMSEAR
| ID: sea-180732
ABSTRACT
Neurological involvement is common in patients infected with HIV. The effectiveness of antiretroviral drugs in lowering the levels of HIV-RNA in cerebrospinal fluid (CSF) is limited by their inability to cross the blood–brain barrier. Discordance in CSF/plasma HIV-RNA levels may have a bearing on the progression of neurological disease in these patients. We report a woman with subacute neurocognitive impairment and abnormal findings on brain MRI, in whom there was a discordance between CSF/plasma HIV-RNA levels. The patient improved after a change in her highly active antiretroviral therapy (HAART) regimen. We also reviewed the available literature on the subject and found seven articles describing 27 patients. Natl Med J India 2015;28228–32
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IMSEAR (Asia Sudoriental)
Idioma:
Inglés
Año:
2015
Tipo del documento:
Artículo
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