In vivo effects of isatin on certain enzymes, lipids & serotonergic system of rat brain.
Artículo
en Inglés
| IMSEAR
| ID: sea-18242
ABSTRACT
Isatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro. At millimolar concentrations (1-10 mM) it inhibited brain acetylcholinesterase (AChE) and sodium, potassium-adenosine triphosphatase (Na+, K(+)-ATPase) activity also. However, isatin did not affect these enzymes after both acute and chronic treatments in vivo. Administration of isatin to rats at 300 mg/kg body weight for 2 and 6 h significantly raised brain serotonin levels. Chronic treatment for 20 days resulted in enhanced brain glycolipids and plasmalogen levels. There was no change in the levels of 5-hydroxy indole acetic acid (5 HIAA), phospholipids, cholesterol and gangliosides under these conditions.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Química Encefálica
/
Masculino
/
Serotonina
/
Inhibidores de la Colinesterasa
/
ATPasa Intercambiadora de Sodio-Potasio
/
Isatina
/
Lípidos
/
Animales
/
Inhibidores de la Monoaminooxidasa
Idioma:
Inglés
Año:
1994
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS