Histocytoarchitectural Changes of Wistar Rat’s Kidney Exposed to Young Coconut Water Before and After Induction with Carbon Tetrachloride.

Background: Young coconut water (YCW) has been used by individuals to boast immunity and that of the experimental animals. In this study an attempt was made to investigate the protective effect of YCW against the Carbon tetrachloride (CCl4) induced renal toxicity in rats. Methods: A total of 20 male adult wistar rats which were not previously subjected to any experiment were divided into four groups. Each group has five rats. Group 1 (Normal control) received basal diet, olive oil and water. Group 2 (Positive control) received basal diet, olive oil and YCW (100ml/kg). Group 3 (Negative control) received basal diet, water and CCl4 diluted with water and olive oil. Group 4 (Experimental group) received basal diet and YCW (100ml/kg) and then intoxicated with CCl4 diluted with water and olive oil. After day 7, the rats were sacrificed and their kidneys were collected and processed histologically following standard protocols. Results: Group 1 (Normal control) displayed normal histocyto-archetature of the kidney. Group 2 (Positive control) revealed hyperplasia with mild inflammatory response. Group 3 (Negative control) showed hypercellularity, mild cystic spaces, necrosis, and loose glomerular membrane indicative of high inflammatory response. Group 4 (Experimental group) revealed moderate cellular activities in line with moderate inflammatory response. Conclusion: The administration of YCW on the rat before intoxication with CCl4 suppresses the deleterious effect of CCl4 on the experimental group.