A Prospective Analysis of Lipid Profile in Children with Type 1 Diabetes in a Tertiary Care Hospital

ABSTRACT

Background: Dyslipidaemia is a significant risk factor for coronary heart disease which may lead to an increased risk of atherosclerosis in Type I diabetes mellitus at a younger age. Methods: This prospective study was conducted in the department of Biochemistry and Paediatrics at Gold Field Institute of Medical Sciences & Research, Faridabad. Twenty children with type 1 diabetes mellitus were enrolled on the basis of inclusion and exclusion criteria and were assessed for the levels of glucose, total cholesterol, triglycerides, High Density Lipoprotein, Very Low Density Lipoprotein, Low Density Lipoprotein and cholesterol to HDL ratio and were compared with same number of matched healthy controls of similar age. Results: The result of the present study showed that all the above mentioned parameters were significantly (P<0.001) higher in type 1 diabetes mellitus as compared to the control group with glucose levels of 207.6 mg/dl, triglycerides levels of 210 mg/dl, cholesterol levels of 250 mg/dl, VLDL levels of 45 mg/dl, LDL levels of 172 mg/dl and cholesterol to HDL ratio of 7.8 whereas HDL levels were significantly lower i.e. 31.2 mg/dl in Type 1 Diabetes Mellitus. Conclusions: The patients are at a higher risk of developing atherosclerosis and dyslipidaemia at an early age.