Study of Metformin Effect on Antimicrobial Property

ABSTRACT

Background: Metformin is believed that marvelous survivor for diabetes and coined as glucose eater among all oral hypoglycemic agents. Antibiotic Resistance is the major issue which compromising the treatment of bacterial, viral, fungal, parasitic infection. The present study showed that effectiveness of metformin drug on microbes. Methods: This study conducted in the department of pharmacology in the carrier institute of medical sciences over a period of six month. Results: Antimicrobial activity of metformin was evaluated against  Gram-positive, Gram-negative bacteria and  fungi using disk diffusion technique of Kierby baur methods. CIP & AK was used as standard antibiotics. Antioxidant potentiality of metformin was investigated by DPPH scavenging activity. Metformin active at 500 μg/ml, showed very good antimicrobial activity against most of the bacterial strains with an average zone of inhibition of 12-15mm. Conclusions: Metformin demonstrated a pronounced inhibitory action against Pseudomonas aeruginosa, an organism which is known to be multidrug resistant. The tested fungi are Candida albicans and Aspergillus niger. The tested drug showed very good antifungal activity with an average 13-17 mm zone of inhibition.