Preemptive Flupirtine in Patients Undergoing Laparoscopic Cholecystectomy for Postoperative Pain Management

ABSTRACT

Background: Postoperative pain after laparoscopic surgery limits the function and mobility of patients in postoperative period. Aim: The aim of present study is to study Flupirtine regarding its efficacy as preemptive analgesic in elective laparoscopic surgeries. Methods: In this randomized prospective study 100 patients were divided into two groups. Group-F received two capsules of Oral Flupirtine 100 mg each and group- P received two multivitamin capsules(placebo) with sip of water 2 hour before the expected time of induction of anaesthesia. Time for requirement of first dose of rescue analgesic post operatively, VAS score and dose of rescue analgesic used in first 24 hours post operatively were assessed. Results: Group F had lower visual analogue score(VAS) score in comparison to P group. Time for requirement of first dose of rescue analgesic in P group was less compared to F group. Consumption of rescue analgesic was less in F group in comparison to P group. Conclusion: Flupirtine as preemptive analgesic produced prolonged postoperative analgesia compared to placebo.