A Comparative Study of Dexmedetomidine Infusion Vs Clonidine Infusion in Maintaining Intra Operative Haemodynamic Stability and Post Op Analgesia Requirment in Laparoscopic Cholecystectomy

Background: Laparoscopic surgery has become the choice for many procedures owing to it’s minimally invasive technique. This not only reduces the post-operative stress, but also improves the overall outcome. However, it is associated with its own complications. Various drugs have been used to counter the haemodynamic fluctuations caused by laparoscopic surgery. α2 agonists have shown good results when used intraoperatively. Aim and Objectives –1 )To compare between inj.Clonidine and inj.Dexmedotamine in attenuation of stress response and haemodynamic stability intra operatively in laparoscopic surgeries. 2) To compare between the analgesia requirement between inj.Clonidine and inj.Dexmedotamine during post-operative period in laparoscopic cholecystectomy surgery. Methods: After obtaining approval from institutional ethical committee and written informed consent from each patient. Sixty patients aged 20-50 years undergoing laparoscopic cholecystectomy were included in the study. Patients were randomly divided into two groups of 30 patients each. Group C (Clonidine) received inj. clonidine 150 μg and group D received inj.dexmedetomidine 150 μg iv in 100ml NS 30 minutes before induction of anaesthesia. Intra-op haemodynamics, post-op pain and side effects were assessed at regular intervals. Results: Dexmedetomidine being a α2 receptor agonist decreases or inhibits the release of the catecholamines and vasopressin. Dexmedetomidine by its sedative, anxiolytic, and analgesic properties, provides a good haemodynamic control and decreased analgesic requirement postoperatively when compared with Clonidine. Conclusion: We conclude that Dexmedetomidine provides a good haemodynamic control and good analgesia when compared to Clonidine in laproscopic cholecystectomy procedures with good monitoring.