Serum Prolidase Activity in Metabolic Syndrome

ABSTRACT

Metabolic syndrome (Mets) is defined as the existence of central obesity, insulin resistance, glucose intolerance, hypertension and dyslipidemia. Prolidase, a member of Matrix metalloproteinases (MMPs), plays an important role in collagen metabolism and extracellular matrix remodelling. Altered Matrix Metalloproteinase (MMPs) is the important factor in the pathogenesis of MetS. Methods: In this study 50 cases with metabolic syndrome diagnosed based on the Adult Treatment panel III ( ATP III ) criteria of the National Cholesterol & Education program (NCEP) and 50 age, sex matched healthy individuals were taken as control. Serum prolidase was estimated by ELISA, fasting plasma glucose, lipid profile, urea & creatinine were estimated by standard methods. Results: The prolidase levels was significantly higher in metabolic syndrome group (41.49±6.59) compared to control group (28.86±3.39) with a p value < 0.05. Statistical analysis were done by SPSS20 software. Conclusion: The serum prolidase values showed positive correlation with waist circumference, SBP, DBP, TG, LDL-C & negative correlation with HDL-C.