A Study on the Clinical and Biochemical Profile of Polycystic Ovary Syndrome Patients Attending a Tertiary Care Hospital in Bihar

ABSTRACT

Background: Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrinological disorders with a broad spectrum of clinical manifestations affecting women of reproductive years. It is a common diagnosis in women presenting with infertility. All the dimensions of PCOS have not been completely explored. Many studies have tried to characterize the exact presentation of the disease. The main objective of this study was to find out the clinical and biochemical profile of patients with polycystic ovary syndrome (PCOS) in patient population attending the tertiary care hospital in Gaya, Bihar. Methods: A cross sectional study was done among 300 PCOS patients in a span of one year. Pregnant patients, patients with symptomatic disease and those of age less than 15 years and more than 35 years were excluded. PCOS patients were diagnosed using Rotterdam’s criteria. A detailed history and examination was obtained. Transvaginal USG was undertaken to detect PCOS. Anthropometric measurements were also done. Biochemical and hormonal test were done by standard methods. Results: The mean age group of patients was 28.11± 4.9 SD with mean BMI 26.12± 5.12. Maximum (42.7%) number of patients was in the age group 26-30 years. Out of 245 fertile patients, 68.6% were nulliparous. Among them, 82.7% had primary infertility. According to duration of infertility, maximum (45.2%) were of 6-10 years duration. About 93.7% were detected to have PCOS in ultrasonography. Androgenic features like acne was present in 22.3% of the patients, acanthosis nigricans in 18% of the patients and androgenic alopecia was present in 7.7%. The prevalence of metabolic syndrome was 21.7% while 20.3% had hypothyroidism. Elevated total testosterone was elevated in 41.3% of the patients. Conclusion: Early diagnosis and intervention will reduce the long term health complications associated with PCOS. A complete clinical, biochemical and radiological workup is necessary for appropriate management.