Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei.
Artículo
en Inglés
| IMSEAR
| ID: sea-19141
ABSTRACT
Administration of picroliv, a standardized fraction of alcoholic extent of Picrorhiza kurroa (3-12 mg/kg/day for two weeks) simultaneously with P. berghei infection showed significant protection against hepatic damage in Mastomys natalensis. The increased levels of serum glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase, lipoprotein-X (LP-X) and bilirubin in the infected animals were marked reduced by different doses of picroliv. In the liver, picroliv decreased the levels of lipid peroxides and hydroperoxides and facilitated the recovery of superoxide dismutase and glycogen. Picroliv had no effect on the degree of parasitaemia.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plasmodium berghei
/
Ácido Vanílico
/
Masculino
/
Extractos Vegetales
/
Cinamatos
/
Glicósidos
/
Parasitosis Hepáticas
/
Animales
/
Malaria
/
Muridae
Idioma:
Inglés
Año:
1990
Tipo del documento:
Artículo
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