Histamine, 5-HT & hyaluronidase in the venom of the scorpion Lychas laevifrons (Pock).
Artículo
en Inglés
| IMSEAR
| ID: sea-19424
ABSTRACT
Factors involved in the pathophysiological changes such as severe pain, burning sensation, redness, swelling and edema in case of the scorpion L. laevifrons were investigated. The presence of pain-producing autacoids histamine 2.1 +/- 0.18 micrograms/mg and 5-HT 0.23 +/- 0.1 micrograms/ml was confirmed by thin layer chromatography and bioassay. Histamine releasing substance was detected in vitro in the chopped guineapig lung. Venom also contained hyaluronidase 5 x 10(-4) N-acetyl-D-glucosamine released/h/mg, which facilitates spread of the toxic principles in the tissues. It is concluded that histamine, 5-HT, histamine-releasing factor and hyaluronidase are partly involved in the pathophysiological changes induced by the venom. It is suggested that mepyramine and cyproheptadine may prove useful in the management of scorpion envenomation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Venenos de Escorpión
/
Histamina
/
Serotonina
/
Cobayas
/
Liberación de Histamina
/
Hialuronoglucosaminidasa
/
Pulmón
/
Animales
Idioma:
Inglés
Año:
1990
Tipo del documento:
Artículo
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