Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.
Artículo
en Inglés
| IMSEAR
| ID: sea-19617
ABSTRACT
Single dose of frusemide 0.1 mg/kg orally was administered in 10 rabbits pretreated with soluble insulin 4 IU intravenously. Induction of diabetes after 24 h was confirmed by an increase in blood sugar and glucosylated haemoglobin and a decrease in serum insulin levels. Ten diabetic rabbits which received only frusemide without insulin pretreatment were used as controls, whereas equal number of insulin-pretreated rabbits receiving hydrochlorothiazide 250 mg/kg orally served as the positive control group. All biochemical parameters remained unaltered in the frusemide-treated test group as well as the positive control group after two weeks. The pancreatotoxic effect of frusemide may induce a stable hyperglycaemic state in rabbits which could lead to a useful diabetic model.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Premedicación
/
Conejos
/
Masculino
/
Administración Oral
/
Diabetes Mellitus Experimental
/
Furosemida
/
Insulina
/
Animales
Idioma:
Inglés
Año:
1993
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS