Cytogenetic Profiles of 472 Indian Children with Acute Myeloid Leukemia
Indian Pediatr
;
2018 Jun; 55(6): 469-473
Artículo
| IMSEAR
| ID: sea-198981
ABSTRACT
Objective:
To analyze the cytogenetic abnormalities of a largecohort of consecutive pediatric Acute Myeloid Leukemia (AML)patients, treated on a uniform protocol.Design:
Review of case records.Setting:
Pediatric Cancer Center of tertiary care hospital betweenJune 2003 and June 2016.Participants:
617 consecutive de novo pediatric AML patientswere screened and 472 patients were found eligible. Eligibilitycriteria included non M3 patients, successful cytogenetic profileand availability of complete recordsMain outcomemeasure:
Cytogenetic profile.Results:
Gum-hypertropy, chloromas and rate of completeremission were significantly different between EuropeanLeukemia Network classification (ELN) cytogenetic risk groups(P<0.01). t (8;21) (141, 29.8%), loss of Y chromosome (61,12.9%)and trisomy 8 (39, 8.3%) were the most common abnormalities.Among the chromosomal gains, trisomy 8 and trisomy 21 (bothP<0.01) were significantly different among the three ELN riskgroups. Among the chromosome losses, monosomy 5, 7 (bothP<0.01) and 9 (P=0.03), loss of X and loss of Y (both P<0.01)were statistically different amongst three cytogenetic risk groups.Event-free survival (P<0.01) and overall survival (P<0.01) werefound to be significantly different among the three risk groups.Conclusions:
The higher frequency of t (8; 21) and its associationwith chloroma in Indian pediatric patients is different from otherstudies around the world.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Revista:
Indian Pediatr
Año:
2018
Tipo del documento:
Artículo
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