The use of Autologous Concentrated Growth Factors in Osseous Regeneration after Periapical Curettage: A Clinical Study

ABSTRACT

Introduction: The contemporary research interest inautologous platelet concentrates is backed by an emergingevidence of their promising regenerative potential in numberof clinical applications. Periapical inflammatory lesionsrepresent a chronic pathology of the periapical tissuesthat result in considerable bone resorption and worsen theoverall tooth prognosis. With this background, the presentstudy was designed to evaluate the effect of the most recentplatelet concentrate preparation, concentrated growth factors(CGF) on osseous regeneration after surgical management ofperiapical lesions.Material and methods: A prospective study was done intwenty patients where CGF was used to fill the periapicaldefects after periapical curettage. Area of radiolucency andmean gray values were assessed at baseline, 1 month, 3months and 6 months after surgery using Image J software.Paired t-test was used to evaluate changes occurring betweenbaseline and 1 month and baseline and 6 months.Results: And early and enhanced healing was evident formthe substantial decrease in area of radiolucency, and meangrayscale values indicated a progressive increase in bonedensity during the observational period. These changes werehighly significant (P< 0.05).Conclusion: CGF can be used as an efficacious and costeffective alternative to conventional bone substitutes forpromoting healing after the surgical debridement of periapicaldefects.